Medical University of South Carolina partners with Shoreline Behavioral Health Services to introduce clinical trials.

Clinical Trial 1: Impact of Lofexidine On Stress, Craving and Opioid Use

The purpose of this study is to determine if the medication lofexidine, taken together with buprenorphine or methadone, is more effective at reducing opioid craving, use and stress response than buprenorphine or methadone alone, and to see if this effect is different for men and women. Participants are randomly assigned to add either lofexidine or placebo to their buprenorphine or methadone treatment for five weeks. They return at the end of five weeks to participate in an opioid imagery task and stress task. Throughout the study, participants complete “CREMA” sessions (Cue Reactivity Ecologic Momentary Assessment) using an iPhone app three times a day. These sessions include looking at stressful and neutral pictures and rating stress and craving.

For more information click here to visit the South Carolina Research Studies Directory
or contact the Program Manager, Lisa Nunn, MS, CCRP at 843-792-0476 or jenkinli@musc.edu

Clinical Trial 2: Medication Treatment For Opioid Use Disorder In Expectant Mothers (MOMS): A Pragmatic Randomized Trial Comparing Extended-Release And Daily Buprenorphine Formulations

The primary purpose of this study is to compare extended-release buprenorphine (CAM2038) to buprenorphine placed under the tongue (sublingual) in pregnant women with opioid use disorder to see if CAM2038 is more effective than sublingual buprenorphine in reducing opioid use and improving newborn outcomes. We are looking to recruit pregnant women who are between 18-41 years old; are between 6-30 weeks pregnant and are not planning to terminate the pregnancy; have opioid use disorder, and willing to enroll in outpatient buprenorphine treatment. Participation in the study would last between 13 and 21 months total with up to between about 63-102 total visits, including weekly medication check visits and research visits.

For more information click here to visit the South Carolina Research Studies Directory
or contact the Program Manager, Lisa Nunn, MS, CCRP at 843-792-0476 or jenkinli@musc.edu